TY - JOUR
T1 - The History of Target-Controlled Infusion
AU - Struys, Michel M. R. F.
AU - De Smet, Tom
AU - Glen, John (Iain) B.
AU - Vereecke, Hugo E. M.
AU - Absalom, Anthony R.
AU - Schnider, Thomas W.
PY - 2016/1
Y1 - 2016/1
N2 - Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.
AB - Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.
KW - COMPUTER-CONTROLLED INFUSION
KW - 3-COMPARTMENT PHARMACOKINETIC MODEL
KW - TOTAL INTRAVENOUS ANESTHESIA
KW - NITROUS-OXIDE ANESTHESIA
KW - LOWER ABDOMINAL-SURGERY
KW - DRIVEN DRUG-DELIVERY
KW - PLASMA-CONCENTRATIONS
KW - ASSISTED INFUSION
KW - BISPECTRAL INDEX
KW - GENERAL-ANESTHESIA
U2 - 10.1213/ANE.0000000000001008
DO - 10.1213/ANE.0000000000001008
M3 - Review article
C2 - 26516804
SN - 0003-2999
VL - 122
SP - 56
EP - 69
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 1
ER -