The History of Target-Controlled Infusion

Michel M. R. F. Struys*, Tom De Smet, John (Iain) B. Glen, Hugo E. M. Vereecke, Anthony R. Absalom, Thomas W. Schnider

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

55 Citaten (Scopus)
199 Downloads (Pure)


Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.

Originele taal-2English
Pagina's (van-tot)56-69
Aantal pagina's14
TijdschriftAnesthesia and Analgesia
Nummer van het tijdschrift1
StatusPublished - jan-2016

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