The Hochberg: Rheumatology, 7e: Biology and immunopathogenesis of vasculitis Elisabeth Brouwer • Peter Heeringa • Cees G.M. Kallenberg

Elisabeth Brouwer, Peter Heeringa, Cees G. M. Kallenberg

OnderzoeksoutputAcademic

Samenvatting

Key Points
■ The interplay between leukocytes and endothelium is important in inflammatory
processes in general and in the pathogenesis of vasculitis in particular.
■ Cytokine-induced endothelial cell activation and leukocyte–endothelium interactions
are coordinated processes underlying differential leukocyte recruitment to sites of
inflammation
■ Immune complex formation and deposition underlie the small-vessel vasculitides in
immunoglobulin A vasculitis (Henoch-Schönlein purpura), anti–glomerular basement
membrane disease, cryoglobulinemic vasculitis, and hypocomplementemic urticarial
vasculitis.
■ Clinical and experimental data suggest but do not prove that antineutrophil
cytoplasmic antibodies (ANCAs) directed against proteinase 3, and myeloperoxidase
are pathogenic in the ANCA-associated small-vessel vasculitides.
■ Toll-like receptor–mediated dendritic cell activation in the adventitia followed by
interferon-γ–producing T helper cell 1 and interleukin-17–producing T helper cell 17
responses to as yet undefined antigen(s) is the major pathogenic event in the
medium- and large-vessel vasculitides
Originele taal-2English
TitelHochberg
SubtitelRheumatology
RedacteurenMichael E. Weinblatt, M.D.
Plaats van productieBoston
UitgeverijElsevier
HoofdstukChapter 162
Pagina's162-1-162-9
Aantal pagina's9
Volume7th
StatusPublished - 1-mrt-2018

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