The immunology of successful pregnancy

A.L. Veenstra van Nieuwenhoven, MJ Heineman, MM Faas*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

191 Citaten (Scopus)


Immune responses play an important role in various reproductive processes, including ovulation, menstruation and parturition. Clearly, during pregnancy, when the mother must accept a semi-allogeneic fetus, immune responses also play a very important role. This was first recognized by Medawar in 1953, when the concept of the fetal allograft was presented in order to explain the immunological relationship between mother and fetus. Since then, the immunology of pregnancy has been the leading subject within reproductive immunology research. Yet, the question of why the semi-allogeneic fetus is not rejected by the mother remains unresolved. The present review provides an update of current knowledge on the subject of the so-called 'immunological paradox of pregnancy'.

Originele taal-2English
Pagina's (van-tot)347-357
Aantal pagina's11
TijdschriftHuman Reproduction Update
Nummer van het tijdschrift4
StatusPublished - jul-2003

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