The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor

Femke F. Wilms; Jolande Y. Vis; Martijn A. Oudijk; Anneke Kwee; Martina M. Porath; Hubertina C. J. Scheepers; Marc E. A. Spaanderman; Kitty W. M. Bloemenkamp; Antoinette C. Bolte; Caroline J. Bax; Jerome M. J. Cornette; Johannes J. Duvekot; Bas W. A. Nij Bijvanck; Jim van Eijck; Maureen T. M. Franssen; Krystyna M. Sollie; Frank P. H. A. Vandenbussche; Mallory D. Woiski; Joris A. M. van der Post; Patrick M. M. Bossuyt; Brent C. Opmeer; Ben W. J. Mol; Gert-Jan van Baaren

doi:10.3109/14767058.2016.1139566

The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor

Femke F. Wilms^*, Jolande Y. Vis, Martijn A. Oudijk, Anneke Kwee, Martina M. Porath, Hubertina C. J. Scheepers, Marc E. A. Spaanderman, Kitty W. M. Bloemenkamp, Antoinette C. Bolte, Caroline J. Bax, Jerome M. J. Cornette, Johannes J. Duvekot, Bas W. A. Nij Bijvanck, Jim van Eijck, Maureen T. M. Franssen, Krystyna M. Sollie, Frank P. H. A. Vandenbussche, Mallory D. Woiski, Joris A. M. van der Post, Patrick M. M. BossuytBrent C. Opmeer, Ben W. J. Mol, Gert-Jan van Baaren

^*Corresponding author voor dit werk

Reproductive Origins of Adult Health and Disease (ROAHD)

Onderzoeksoutput: Article › Academic › peer review

16 Citaten (Scopus)

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Objective: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD).Methods: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated.Results: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p=0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)).Conclusions: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.

Originele taal-2	English
Pagina's (van-tot)	3563-3569
Aantal pagina's	7
Tijdschrift	Journal of Maternal-Fetal & Neonatal Medicine
Volume	29
Nummer van het tijdschrift	21
DOI's	https://doi.org/10.3109/14767058.2016.1139566
Status	Published - nov.-2016

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Wilms, F. F., Vis, J. Y., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C. J., Spaanderman, M. E. A., Bloemenkamp, K. W. M., Bolte, A. C., Bax, C. J., Cornette, J. M. J., Duvekot, J. J., Bijvanck, B. W. A. N., van Eijck, J., Franssen, M. T. M., Sollie, K. M., Vandenbussche, F. P. H. A., Woiski, M. D., van der Post, J. A. M., ... van Baaren, G.-J. (2016). The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor. Journal of Maternal-Fetal & Neonatal Medicine, 29(21), 3563-3569. https://doi.org/10.3109/14767058.2016.1139566

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title = "The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor",

abstract = "Objective: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD).Methods: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated.Results: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p=0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)).Conclusions: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.",

keywords = "Ethnicity, fetal gender, preterm delivery, preterm labor, CERVICAL LENGTH, GESTATIONAL-AGE, BIRTH, SEX, FIBRONECTIN, ASSOCIATION, PREDICTION, EPIDEMIOLOGY, DISPARITIES, COHORT",

author = "Wilms, {Femke F.} and Vis, {Jolande Y.} and Oudijk, {Martijn A.} and Anneke Kwee and Porath, {Martina M.} and Scheepers, {Hubertina C. J.} and Spaanderman, {Marc E. A.} and Bloemenkamp, {Kitty W. M.} and Bolte, {Antoinette C.} and Bax, {Caroline J.} and Cornette, {Jerome M. J.} and Duvekot, {Johannes J.} and Bijvanck, {Bas W. A. Nij} and {van Eijck}, Jim and Franssen, {Maureen T. M.} and Sollie, {Krystyna M.} and Vandenbussche, {Frank P. H. A.} and Woiski, {Mallory D.} and {van der Post}, {Joris A. M.} and Bossuyt, {Patrick M. M.} and Opmeer, {Brent C.} and Mol, {Ben W. J.} and {van Baaren}, Gert-Jan",

year = "2016",

month = nov,

doi = "10.3109/14767058.2016.1139566",

language = "English",

volume = "29",

pages = "3563--3569",

journal = "Journal of Maternal-Fetal & Neonatal Medicine",

issn = "1476-7058",

publisher = "Taylor & Francis Ltd",

number = "21",

}

Wilms, FF, Vis, JY, Oudijk, MA, Kwee, A, Porath, MM, Scheepers, HCJ, Spaanderman, MEA, Bloemenkamp, KWM, Bolte, AC, Bax, CJ, Cornette, JMJ, Duvekot, JJ, Bijvanck, BWAN, van Eijck, J, Franssen, MTM, Sollie, KM, Vandenbussche, FPHA, Woiski, MD, van der Post, JAM, Bossuyt, PMM, Opmeer, BC, Mol, BWJ & van Baaren, G-J 2016, 'The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor', Journal of Maternal-Fetal & Neonatal Medicine, vol. 29, nr. 21, blz. 3563-3569. https://doi.org/10.3109/14767058.2016.1139566

TY - JOUR

T1 - The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor

AU - Wilms, Femke F.

AU - Vis, Jolande Y.

AU - Oudijk, Martijn A.

AU - Kwee, Anneke

AU - Porath, Martina M.

AU - Scheepers, Hubertina C. J.

AU - Spaanderman, Marc E. A.

AU - Bloemenkamp, Kitty W. M.

AU - Bolte, Antoinette C.

AU - Bax, Caroline J.

AU - Cornette, Jerome M. J.

AU - Duvekot, Johannes J.

AU - Bijvanck, Bas W. A. Nij

AU - van Eijck, Jim

AU - Franssen, Maureen T. M.

AU - Sollie, Krystyna M.

AU - Vandenbussche, Frank P. H. A.

AU - Woiski, Mallory D.

AU - van der Post, Joris A. M.

AU - Bossuyt, Patrick M. M.

AU - Opmeer, Brent C.

AU - Mol, Ben W. J.

AU - van Baaren, Gert-Jan

PY - 2016/11

Y1 - 2016/11

N2 - Objective: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD).Methods: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated.Results: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p=0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)).Conclusions: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.

AB - Objective: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD).Methods: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated.Results: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p=0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)).Conclusions: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.

KW - Ethnicity

KW - fetal gender

KW - preterm delivery

KW - preterm labor

KW - CERVICAL LENGTH

KW - GESTATIONAL-AGE

KW - BIRTH

KW - SEX

KW - FIBRONECTIN

KW - ASSOCIATION

KW - PREDICTION

KW - EPIDEMIOLOGY

KW - DISPARITIES

KW - COHORT

U2 - 10.3109/14767058.2016.1139566

DO - 10.3109/14767058.2016.1139566

M3 - Article

SN - 1476-7058

VL - 29

SP - 3563

EP - 3569

JO - Journal of Maternal-Fetal & Neonatal Medicine

JF - Journal of Maternal-Fetal & Neonatal Medicine

IS - 21

ER -

The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor

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