TY - JOUR
T1 - The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients
AU - Schaake, Wouter
AU - Wiegman, Erwin M
AU - de Groot, Martijn
AU - van der Laan, Hans Paul
AU - van der Schans, Cees P.
AU - van den Bergh, Alfons C M
AU - Langendijk, Johannes A
N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
PY - 2014/2
Y1 - 2014/2
N2 - PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer.PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events version 3.0 were used to grade late genitourinary and gastrointestinal toxicity. The European Organization for Research and Treatment of Cancer Quality of life Questionnaire C30 (EORTC QLQ-C30) was used to assess HRQoL at baseline, and 6, 12 and 24 months after completion of radiotherapy. Statistical analysis was performed using a multivariate analysis of variance (MANOVA).RESULTS: Urinary incontinence and rectal discomfort significantly affected HRQoL. The impact of urinary incontinence on HRQoL was most pronounced 6 months after radiotherapy and gradually decreased over time. The impact of rectal discomfort on HRQoL was predominant at 6 months after radiotherapy, decreased at 12 months and increased again 2 years after radiotherapy. No significant impact on HRQoL was observed for any of the other toxicity endpoints, or non-toxicity related factors such as hormonal therapy, radiotherapy technique or age.CONCLUSION: Urinary incontinence and rectal discomfort have a significant impact on HRQoL. Prevention of these side effects may likely improve quality of life of prostate cancer patients after completion of treatment.
AB - PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer.PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events version 3.0 were used to grade late genitourinary and gastrointestinal toxicity. The European Organization for Research and Treatment of Cancer Quality of life Questionnaire C30 (EORTC QLQ-C30) was used to assess HRQoL at baseline, and 6, 12 and 24 months after completion of radiotherapy. Statistical analysis was performed using a multivariate analysis of variance (MANOVA).RESULTS: Urinary incontinence and rectal discomfort significantly affected HRQoL. The impact of urinary incontinence on HRQoL was most pronounced 6 months after radiotherapy and gradually decreased over time. The impact of rectal discomfort on HRQoL was predominant at 6 months after radiotherapy, decreased at 12 months and increased again 2 years after radiotherapy. No significant impact on HRQoL was observed for any of the other toxicity endpoints, or non-toxicity related factors such as hormonal therapy, radiotherapy technique or age.CONCLUSION: Urinary incontinence and rectal discomfort have a significant impact on HRQoL. Prevention of these side effects may likely improve quality of life of prostate cancer patients after completion of treatment.
KW - Prostate cancer
KW - Radiotherapy
KW - Gastrointestinal side effects
KW - Genitourinary side effects
KW - Health-related quality of life
KW - EXTERNAL-BEAM RADIOTHERAPY
KW - INTENSITY-MODULATED RADIOTHERAPY
KW - TISSUE COMPLICATION PROBABILITY
KW - CONFORMAL RADIOTHERAPY
KW - RADICAL PROSTATECTOMY
KW - RADIATION PROCTITIS
KW - RECTAL TOXICITY
KW - GRADING-SYSTEM
KW - 78 GY
KW - INCONTINENCE
U2 - 10.1016/j.radonc.2013.11.011
DO - 10.1016/j.radonc.2013.11.011
M3 - Article
C2 - 24411226
SN - 0167-8140
VL - 110
SP - 284
EP - 290
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 2
ER -