TY - JOUR
T1 - The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent
AU - van Walraven, Suzanna M.
AU - Brand, Anneke
AU - Bakker, Jack N. A.
AU - Heemskerk, Martin B. A.
AU - Nillesen, Suzan
AU - Bierings, Marc B.
AU - Bungener, Laura B.
AU - Hepkema, Bouke G.
AU - Lankester, Arjan
AU - van der Meer, Arnold
AU - Sintnicolaas, Kees
AU - Somers, Judith A. E.
AU - Spierings, Eric
AU - Tilanus, Marcel G. J.
AU - Voorter, Christien E. M.
AU - Cornelissen, Jan J.
AU - Oudshoorn, Machteld
PY - 2017/1
Y1 - 2017/1
N2 - Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P
AB - Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P
KW - HEMATOPOIETIC-CELL TRANSPLANTATION
KW - CORD BLOOD TRANSPLANTATION
KW - HLA MATCH
KW - HEMATOLOGIC MALIGNANCY
KW - OUTCOMES
KW - SEARCH
KW - ALLELE
KW - AVAILABILITY
KW - ENGRAFTMENT
KW - GENERATION
U2 - 10.3324/haematol.2016.145730
DO - 10.3324/haematol.2016.145730
M3 - Article
SN - 0390-6078
VL - 102
SP - 176
EP - 183
JO - Haematologica
JF - Haematologica
IS - 1
ER -