The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries

Annet M. Aukes, Nicole Bishop, Julie Godfrey, Marilyn J. Cipolla*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    13 Citaten (Scopus)


    The authors investigated the influence of pregnancy and gender on the density of trigeminal and sympathetic perivascular nerves in posterior cerebral arteries (PCA) and the reactivity to norepinephrine and calcitonin gene-related peptide (CGRP). PCAs were isolated from nonpregnant, late-pregnant, postpartum, and male rats, mounted and pressurized on an arteriograph chamber to obtain concentration-response curves to norepinephrine and CGRP. Arteries were immunostained for CGRP-, tyrosine hydroxylase, and protein gene product 9.5 (PGP 9.5)-containing perivascular nerves, and nerve density was determined morphologically. Pregnancy had a trophic effect on trigeminal perivascular innervation (P

    Originele taal-2English
    Pagina's (van-tot)411-419
    Aantal pagina's9
    TijdschriftReproductive Sciences
    Nummer van het tijdschrift4
    StatusPublished - apr-2008

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