The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Mireia Niso-Santano, Elisa Pizarro-Estrella, Ana Aiastui-Pujana, Ana Gorostidi, Vicente Climent, Rakel López De Maturana, Rosario Sanchez-Pernaute, Adolfo López De Munain, José M. Fuentes, Rosa A. Gonźlez-Polo

OnderzoeksoutputAcademicpeer review

21 Citaten (Scopus)

Samenvatting

The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway.
Originele taal-2English
Pagina's (van-tot)1537-1539
Aantal pagina's3
TijdschriftAutophagy
Volume8
Nummer van het tijdschrift10
DOI's
StatusPublished - 2012
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts'. Samen vormen ze een unieke vingerafdruk.

Citeer dit