The metabolic syndrome and related characteristics in major depression: inpatients and outpatients compared Metabolic differences across treatment settings

Floriana S. Luppino*, Paul F. Bouvy, Erik J. Giltay, Brenda W. J. H. Penninx, Frans G. Zitman

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    13 Citaten (Scopus)


    Objective: We aimed to systematically compare patients with major depressive disorder from three different treatment settings (a primary care outpatient, a secondary care outpatient and one inpatient sample), with regard to metabolic syndrome (MetSyn) prevalences, individual MetSyn components and related metabolic variables.

    Method: The outpatient samples were drawn from the ongoing Netherlands Study of Depression and Anxiety (302 primary care and 445 secondary care outpatients). The inpatient sample (n=80) was recruited from five Dutch mental health hospitals. The assessments of MetSyn and related variables [waist circumference (WC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, glucose, systolic and diastolic blood pressure (SBP, DBP), body mass index (BMI), waist-hip ratio (WHR), LDL and total cholesterol (TC)] were compared using analysis of (co)variance and regression analysis, whereas medication analyses examined the extent to which clinical differences (e. g., depression severity or medication use) mediated the observed metabolic differences across setting.

    Results: MetSyn prevalences (26% primary, 24% secondary care and 28% inpatients) did not significantly differ (P=.71). WC, BMI, LDL cholesterol, glucose and DBP were not significantly different across settings. However, WHR, TC and triglyceride levels were higher in inpatients than in both outpatients groups, while HDL cholesterol levels and SBP were lower. There was some mediating role for tricyclic and non-selective serotonin-reuptake inhibitor antidepressant use, but overall, the mediating role of clinical differences was limited.

    Conclusions: Although overall MetSyn prevalences did not differ, patterns of individual MetSyn-related variables differed more markedly across depressed inpatients and outpatients. Inpatients showed more adverse WHR and serum lipid profiles, while SBP levels were lower. (C) 2014 Elsevier Inc. All rights reserved.

    Originele taal-2English
    Pagina's (van-tot)509-515
    Aantal pagina's7
    TijdschriftGeneral Hospital Psychiatry
    Nummer van het tijdschrift5
    StatusPublished - sep-2014

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