The multiple functions of the co-chaperone stress inducible protein 1

Anna Carolina Carvalho da Fonseca, Diana Matias, Luiz Henrique Medeiros Geraldo, Felipe Saceanu Leser, Iohana Pagnoncelli, Celina Garcia, Rackele Ferreira do Amaral, Barbara Gomes da Rosa, Izabella Grimaldi, Eduardo Sabino de Camargo Magalhães, Valentín Cóppola-Segovia, Evellyn Mayla de Azevedo, Silvio Marques Zanata, Flavia Regina Souza Lima

    Onderzoeksoutputpeer review

    12 Citaten (Scopus)
    80 Downloads (Pure)


    Stress inducible protein 1 (STI1) is a co-chaperone acting with Hsp70 and Hsp90 for the correct client proteins' folding and therefore for the maintenance of cellular homeostasis. Besides being expressed in the cytosol, STI1 can also be found both in the cell membrane and the extracellular medium playing several relevant roles in the central nervous system (CNS) and tumor microenvironment. During CNS development, in association with cellular prion protein (PrPc), STI1 regulates crucial events such as neuroprotection, neuritogenesis, astrocyte differentiation and survival. In cancer, STI1 is involved with tumor growth and invasion, is undoubtedly a pro-tumor factor, being considered as a biomarker and possibly therapeutic target for several malignancies. In this review, we discuss current knowledge and new findings on STI1 function as well as its role in tissue homeostasis, CNS and tumor progression.

    Originele taal-2English
    Pagina's (van-tot)73-84
    Aantal pagina's12
    TijdschriftCytokine & growth factor reviews
    StatusPublished - feb.-2021

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