The nature and identification of quantitative trait loci: a community's view

O Abiola; JM Angel; P Avner; AA Bachmanov; JK Belknap; B Bennett; EP Blankenhorn; DA Blizard; [No Value] Bolivar; GA Brockmann; KJ Buck; JF Bureau; WL Casley; EJ Chesler; JM Cheverud; GA Churchill; M Cook; JC Crabbe; WE Crusio; A Darvasi; G de Haan; P Demant; RW Doerge; RW Elliott; CR Farber; L Flaherty; J Flint; H Gershenfeld; JPGJ Gu; WK Gu; H Himmelbauer; R Hitzemann; HC Hsu; K Hunter; FA Iraqi; RC Jansen; TE Johnson; BC Jones; G Kempermann; F Lammert; L Lu; KF Manly; DB Matthews; JF Medrano; M Mehrabian; G Mittleman; BA Mock; JS Mogil; [No Value] Montagutelli; G Morahan; Complex Trait Consortium

doi:10.1038/nrg1206

The nature and identification of quantitative trait loci: a community's view

O Abiola
, JM Angel
, P Avner
, AA Bachmanov
, JK Belknap
, B Bennett
, EP Blankenhorn
, DA Blizard
, [No Value] Bolivar
, GA Brockmann
, KJ Buck
, JF Bureau
, WL Casley
, EJ Chesler
, JM Cheverud
, GA Churchill
, M Cook
, JC Crabbe
, WE Crusio
, A Darvasi

G de Haan, P Demant, RW Doerge, RW Elliott, CR Farber, L Flaherty, J Flint, H Gershenfeld, JPGJ Gu, WK Gu, H Himmelbauer, R Hitzemann, HC Hsu, K Hunter, FA Iraqi, RC Jansen, TE Johnson, BC Jones, G Kempermann, F Lammert, L Lu, KF Manly, DB Matthews, JF Medrano, M Mehrabian, G Mittleman, BA Mock, JS Mogil, [No Value] Montagutelli, G Morahan, Complex Trait Consortium

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393 Citaten (Scopus)

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This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Originele taal-2	English
Pagina's (van-tot)	911-916
Aantal pagina's	6
Tijdschrift	Nature Reviews Genetics
Volume	4
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1038/nrg1206
Status	Published - nov.-2003

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Abiola, O., Angel, JM., Avner, P., Bachmanov, AA., Belknap, JK., Bennett, B., Blankenhorn, EP., Blizard, DA., Bolivar, N. V., Brockmann, GA., Buck, KJ., Bureau, JF., Casley, WL., Chesler, EJ., Cheverud, JM., Churchill, GA., Cook, M., Crabbe, JC., Crusio, WE., ... Complex Trait Consortium (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics, 4(11), 911-916. https://doi.org/10.1038/nrg1206

@article{3dee453dbe084b4eacbba9ff5329fb3c,

title = "The nature and identification of quantitative trait loci: a community's view",

abstract = "This white paper by eighty members of the Complex Trait Consortium presents a community{\textquoteright}s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?",

keywords = "GENETIC DISSECTION, PREFERENCE DRINKING, COMPLEX TRAITS, MICE, ALCOHOL, STRAINS, LINKAGE, LINES, QTL, POPULATION",

author = "O Abiola and JM Angel and P Avner and AA Bachmanov and JK Belknap and B Bennett and EP Blankenhorn and DA Blizard and Bolivar, \{[No Value]\} and GA Brockmann and KJ Buck and JF Bureau and WL Casley and EJ Chesler and JM Cheverud and GA Churchill and M Cook and JC Crabbe and WE Crusio and A Darvasi and \{de Haan\}, G and P Demant and RW Doerge and RW Elliott and CR Farber and L Flaherty and J Flint and H Gershenfeld and JPGJ Gu and WK Gu and H Himmelbauer and R Hitzemann and HC Hsu and K Hunter and FA Iraqi and RC Jansen and TE Johnson and BC Jones and G Kempermann and F Lammert and L Lu and KF Manly and DB Matthews and JF Medrano and M Mehrabian and G Mittleman and BA Mock and JS Mogil and Montagutelli, \{[No Value]\} and G Morahan and \{Complex Trait Consortium\}",

note = "Relation: http://www.rug.nl/ Rights: http://rs.ub.rug.nl/keur/",

year = "2003",

month = nov,

doi = "10.1038/nrg1206",

language = "English",

volume = "4",

pages = "911--916",

journal = "Nature Reviews Genetics",

issn = "1471-0056",

publisher = "Nature Publishing Group",

number = "11",

}

Abiola, O, Angel, JM, Avner, P, Bachmanov, AA, Belknap, JK, Bennett, B, Blankenhorn, EP, Blizard, DA, Bolivar, NV, Brockmann, GA, Buck, KJ, Bureau, JF, Casley, WL, Chesler, EJ, Cheverud, JM, Churchill, GA, Cook, M, Crabbe, JC, Crusio, WE, Darvasi, A, de Haan, G, Demant, P, Doerge, RW, Elliott, RW, Farber, CR, Flaherty, L, Flint, J, Gershenfeld, H, Gu, JPGJ, Gu, WK, Himmelbauer, H, Hitzemann, R, Hsu, HC, Hunter, K, Iraqi, FA, Jansen, RC, Johnson, TE, Jones, BC, Kempermann, G, Lammert, F, Lu, L, Manly, KF, Matthews, DB, Medrano, JF, Mehrabian, M, Mittleman, G, Mock, BA, Mogil, JS, Montagutelli, NV, Morahan, G & Complex Trait Consortium 2003, 'The nature and identification of quantitative trait loci: a community's view', Nature Reviews Genetics, vol. 4, nr. 11, blz. 911-916. https://doi.org/10.1038/nrg1206

TY - JOUR

T1 - The nature and identification of quantitative trait loci

T2 - a community's view

AU - Abiola, O

AU - Angel, JM

AU - Avner, P

AU - Bachmanov, AA

AU - Belknap, JK

AU - Bennett, B

AU - Blankenhorn, EP

AU - Blizard, DA

AU - Bolivar, [No Value]

AU - Brockmann, GA

AU - Buck, KJ

AU - Bureau, JF

AU - Casley, WL

AU - Chesler, EJ

AU - Cheverud, JM

AU - Churchill, GA

AU - Cook, M

AU - Crabbe, JC

AU - Crusio, WE

AU - Darvasi, A

AU - de Haan, G

AU - Demant, P

AU - Doerge, RW

AU - Elliott, RW

AU - Farber, CR

AU - Flaherty, L

AU - Flint, J

AU - Gershenfeld, H

AU - Gu, JPGJ

AU - Gu, WK

AU - Himmelbauer, H

AU - Hitzemann, R

AU - Hsu, HC

AU - Hunter, K

AU - Iraqi, FA

AU - Jansen, RC

AU - Johnson, TE

AU - Jones, BC

AU - Kempermann, G

AU - Lammert, F

AU - Lu, L

AU - Manly, KF

AU - Matthews, DB

AU - Medrano, JF

AU - Mehrabian, M

AU - Mittleman, G

AU - Mock, BA

AU - Mogil, JS

AU - Montagutelli, [No Value]

AU - Morahan, G

AU - Complex Trait Consortium

N1 - Relation: http://www.rug.nl/ Rights: http://rs.ub.rug.nl/keur/

PY - 2003/11

Y1 - 2003/11

N2 - This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

AB - This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

KW - GENETIC DISSECTION

KW - PREFERENCE DRINKING

KW - COMPLEX TRAITS

KW - MICE

KW - ALCOHOL

KW - STRAINS

KW - LINKAGE

KW - LINES

KW - QTL

KW - POPULATION

U2 - 10.1038/nrg1206

DO - 10.1038/nrg1206

M3 - Review article

SN - 1471-0056

VL - 4

SP - 911

EP - 916

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

IS - 11

ER -

The nature and identification of quantitative trait loci: a community's view

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