The peroxisome biogenesis factors Pex3 and Pex19: Multitasking proteins with disputed functions

Renate L M Jansen, Ida J van der Klei*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

26 Citaten (Scopus)
24 Downloads (Pure)

Samenvatting

The peroxisomal membrane protein Pex3 and its cytosolic interaction partner Pex19 have been implicated in peroxisomal membrane biogenesis. Although these peroxins have been extensively studied, no consensus has been reached yet on how they operate. Here, we discuss two major models of their function, namely, in direct insertion of proteins into the peroxisomal membrane or in formation of peroxisomal membrane protein-containing vesicles from the endoplasmic reticulum. Pex3 can also recruit other proteins to the peroxisomal membrane (e.g. Inp1, Atg30, Atg36), thereby fulfilling roles in other processes such as autophagy and organelle retention. Recent studies indicate that Pex3 and Pex19 can also facilitate sorting of certain membrane proteins to other cellular organelles, including the endoplasmic reticulum, lipid droplets and mitochondria. This article is protected by copyright. All rights reserved.

Originele taal-2English
Pagina's (van-tot)457-474
Aantal pagina's18
TijdschriftFEBS Letters
Volume593
Nummer van het tijdschrift5
Vroegere onlinedatum18-feb-2019
DOI's
StatusPublished - mrt-2019

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