The Regulation of the Autophagic Network and Its Implications for Human Disease

Jing Yang, Serena Carra, Wei-Guo Zhu, Harm H. Kampinga*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

22 Citaten (Scopus)
199 Downloads (Pure)


Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.

Originele taal-2English
Pagina's (van-tot)1121-1133
Aantal pagina's13
TijdschriftInternational Journal of Biological Sciences
Nummer van het tijdschrift10
StatusPublished - 2013

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