The Relationship Between Electrocerebral Activity and Cerebral Fractional Tissue Oxygen Extraction in Preterm Infants

Hendrik J. Ter Horst*, Elise A. Verhagen, Paul Keating, Arend F. Bos

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

23 Citaten (Scopus)


Impaired cerebral oxygen delivery may cause cerebral damage in preterm infants. At lower levels of cerebral perfusion and oxygen concentration, electrocerebral activity is disturbed. The balance between cerebral oxygen delivery and oxygen use can be measured by near-infrared spectroscopy (NIRS), and electrocerebral activity can be measured by amplitude-integrated EEG (aEEG). Our aim was to determine the relationship between regional cerebral tissue oxygen saturation (r(c)SO(2)), fractional tissue oxygen extraction (FTOE), and aEEG. We recorded longitudinal digital aEEG and r(c)SO(2) prospectively in 46 preterm infants (mean GA 29.5 wk, SD 1.7) for 2 hr on the 1st to 5th, 8th, and 15th d after birth. We excluded infants with germinal matrix hemorrhage exceeding grade I and recordings of infants receiving inotropes. FTOE was calculated using transcutaneous arterial oxygen saturation (tcSaO(2)) and r(c)SO(2) values: (tcSaO(2) - r(c)SO(2))/tcSaO(2). aEEG was assessed by calculating the mean values of the 5th, 50th, and 95th centiles of the aEEG amplitudes. The aEEG amplitude centiles changed with increasing GA. FTOE and aEEG amplitude centiles increased significantly with postnatal age. More mature electrocerebral activity was accompanied by increased FTOE. FTOE also increased with increasing postnatal age and decreasing Hb levels. (Pediatr Res 70: 384-388, 2011)

Originele taal-2English
Pagina's (van-tot)384-388
Aantal pagina's5
TijdschriftPediatric Research
Nummer van het tijdschrift4
StatusPublished - okt-2011

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