The relationship between inflammation and the coagulation system

Goda Choi, Marcus J. Schultz, Marcel Levi, Tom van der Poll

OnderzoeksoutputAcademicpeer review

50 Citaten (Scopus)
51 Downloads (Pure)


Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old responses, there is extensive cross-talk between inflammation and coagulation in enabling an adequate immune response against potentially injurious stimuli. Immune cells are important in the initiation of coagulation pathways, while various inflammatory mediators are capable of altering haemostasis. Vice versa, coagulation proteases have significant immunomodulatory effects. Understanding the mechanisms involved in the crosstalk between inflammation and coagulation may yield new therapeutic strategies for human diseases.

Originele taal-2English
Pagina's (van-tot)139-144
Aantal pagina's6
TijdschriftSwiss medical weekly
Nummer van het tijdschrift9-10
StatusPublished - 2006
Extern gepubliceerdJa

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