Cells make use of autophagy to turnover and recycle damaged or superfluous cellular components, and to adapt to nutrient deprivation conditions. The basic mechanism of this pathway is the sequestration of structures targeted to degradation by large double-membrane vesicles called autophagosomes. Genetic screens have identified numerous autophagy-related genes (ATG) that act during autophagosome biogenesis. Most of them are peripheral membrane proteins with Atg9 being the only conserved transmembrane protein essential for autophagy. Although the precise function of this protein is still unknown, Atg9 probably acts as a recruitment hub for several other Atg proteins at the site of autophagosome formation and as a result it is one of the factors playing a central role in autophagy regulation. Therefore understanding the molecular contribution of Atg9 to autophagy will be critical to unveil the molecular mechanism of this pathway. In this chapter we review the current knowledge about Atg9, with particular focus on the yeast Saccharomyces cerevisiae model and discuss open questions regarding this protein.
|Subtitel||Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging|
|ISBN van geprinte versie||978-0-12-805420-8|
|Status||Published - 2017|