The role of mucosal inflammation in initiation of rheumatoid arthritis

Koen Martin Jan Janssen

The role of mucosal inflammation in initiation of rheumatoid arthritis

Koen Martin Jan Janssen

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Reumatoïde artritis is een auto-immuunziekte die is gekarakteriseerd door chronische ontsteking van synoviale gewrichten wat kan leiden tot onomkeerbare gewrichtsschade. Vroege behandeling is van groot belang om progressie van de ziekte te stoppen. Vroege herkenning is daarom erg belangrijk. Reumatoïde artritis is gekarakteriseerd door de aanwezigheid van autoantistoffen gericht tegen gecitrullineerde eiwitten (ACPA) en reumafactor (RF).

Het onderzoek focuste op de vraag of mucosale ontsteking, zoals parodontitis, chronische ontsteking van de longen en IBD de productie van autoantistoffen kenmerkend voor reumatoïde artritis stimuleert. Met name parodontitis is gesuggereerd een rol te spelen bij de initiatie van reumatoïde artritis geassocieerde autoantistoffen door de bacterie Porphyromonas gingivalis.

Inderdaad bleek dat de aanwezigheid van deze autoantistoffen in patienten zonder reumatoide artritis was geassocieerd met parodontitis en chronische ontsteking van de longen, alhoewel de speigels over het algemeen laag waren. Ook werden immunologische veranderingen in seropositive artralgia patiënten (ACPA en/of RF positief) onderzocht om immuun markers te identificeren die mogelijk een rol spelen in de ontwikkeling van reumatoïde artritis.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Vissink, Arjan, Supervisor Winkelhoff ,van, Arie, Supervisor Westra, Hannie, Co-supervisor Brouwer, Liesbeth, Co-supervisor
Datum van toekenning	21-nov.-2016
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Gedrukte ISBN's	978-94-6182-738-8
Elektronische ISBN's	978-94-6182-739-5
Status	Published - 2016

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Title and contents Final publisher's version, 98,1 KB
Chapter 1 Final publisher's version, 697 KB
Chapter 2 Final publisher's version, 1,86 MB
Chapter 3 Final publisher's version, 600 KB
Chapter 4 Final publisher's version, 7,57 MB
Chapter 5 Final publisher's version, 743 KB
Chapter 6 Final publisher's version, 341 KB
Chapter 7 Final publisher's version, 945 KB
Chapter 8 Final publisher's version, 499 KB
Chapter 9 Final publisher's version, 467 KB
Complete thesisFinal publisher's version, 11,1 MB
PropositionsFinal publisher's version, 28 KB

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title = "The role of mucosal inflammation in initiation of rheumatoid arthritis",

abstract = "Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the synovial joints resulting in irreversible damage to bone and cartilage. Early treatment is of paramount importance to stop progression of the disease. Early recognition is therefore very important. Rheumatoid arthritis is characterized by the presence of autoantibodies directed against self citrullinated proteins (ACPA) and rheumatoid factor (RF). Present research focused on the question whether mucosal inflammation, viz., periodontitis, chronic inflammation of lung mucosal tissues and inflammatory bowel disease predispose to rheumatoid arthritis associated autoantibody production. Periodontitis in particular has been suggested to predispose for the production of rheumatoid arthritis associated autoantibodies via the periodontal pathogen Porphyromonas gingivalis.Indeed, presence of these autoantibodies in patients without rheumatoid arthritis was associated with periodontitis or lung mucosal inflammation, although overall levels were low. Another aim was to investigate immunological alterations in seropositive arthralgia patients (ACPA and/or RF positive) to identify immune markers that may be involved in disease development.",

author = "Janssen, {Koen Martin Jan}",

year = "2016",

language = "English",

isbn = "978-94-6182-738-8",

publisher = "Rijksuniversiteit Groningen",

school = "University of Groningen",

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T1 - The role of mucosal inflammation in initiation of rheumatoid arthritis

AU - Janssen, Koen Martin Jan

PY - 2016

Y1 - 2016

N2 - Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the synovial joints resulting in irreversible damage to bone and cartilage. Early treatment is of paramount importance to stop progression of the disease. Early recognition is therefore very important. Rheumatoid arthritis is characterized by the presence of autoantibodies directed against self citrullinated proteins (ACPA) and rheumatoid factor (RF). Present research focused on the question whether mucosal inflammation, viz., periodontitis, chronic inflammation of lung mucosal tissues and inflammatory bowel disease predispose to rheumatoid arthritis associated autoantibody production. Periodontitis in particular has been suggested to predispose for the production of rheumatoid arthritis associated autoantibodies via the periodontal pathogen Porphyromonas gingivalis.Indeed, presence of these autoantibodies in patients without rheumatoid arthritis was associated with periodontitis or lung mucosal inflammation, although overall levels were low. Another aim was to investigate immunological alterations in seropositive arthralgia patients (ACPA and/or RF positive) to identify immune markers that may be involved in disease development.

AB - Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the synovial joints resulting in irreversible damage to bone and cartilage. Early treatment is of paramount importance to stop progression of the disease. Early recognition is therefore very important. Rheumatoid arthritis is characterized by the presence of autoantibodies directed against self citrullinated proteins (ACPA) and rheumatoid factor (RF). Present research focused on the question whether mucosal inflammation, viz., periodontitis, chronic inflammation of lung mucosal tissues and inflammatory bowel disease predispose to rheumatoid arthritis associated autoantibody production. Periodontitis in particular has been suggested to predispose for the production of rheumatoid arthritis associated autoantibodies via the periodontal pathogen Porphyromonas gingivalis.Indeed, presence of these autoantibodies in patients without rheumatoid arthritis was associated with periodontitis or lung mucosal inflammation, although overall levels were low. Another aim was to investigate immunological alterations in seropositive arthralgia patients (ACPA and/or RF positive) to identify immune markers that may be involved in disease development.

M3 - Thesis fully internal (DIV)

SN - 978-94-6182-738-8

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

The role of mucosal inflammation in initiation of rheumatoid arthritis

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