The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: Results from two longitudinal studies

G. Snijders*, L. de Witte, E. Mesman, S. Kemner, R. Vonk, R. Brouwer, W. A. Nolen, H. A. Drexhage, M. H. J. Hillegers

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)
210 Downloads (Pure)


Background: Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence's and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a mood disorder) compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor (trait marker) for BD development.

Objectives: Here we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a 'trait' marker for BD. The present study aims to investigate whether TPO-Abs (1) are stable over time, (2) are associated with lithium-exposure, (3) share a common genetic background with BD and are related to psychopathology.

Results: In bipolar offspring and twins, the prevalence of TPO-Abs is stable over time (r(s) = .72 p <.001 resp. r(s) = .82, p

Conclusions: Although our results show a trend toward an increased inherited risk of the co-occurrence of BD and thyroid autoimmunity, large-scale studies can only draw final conclusions. Nationwide epidemiological and GWAS studies reach such numbers and support the view of a possible common (autoimmune) etiology of severe mood disorders and chronic recurrent infections and autoimmunity, including thyroid autoimmunity.

Originele taal-2English
Aantal pagina's6
TijdschriftInternational Journal of Bipolar Disorders
Nummer van het tijdschrift1
StatusPublished - 20-jan-2017

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