Samenvatting
A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (chi(2)=4.16, p=.042 and chi(2)=3.90, p=.048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
Originele taal-2 | English |
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Pagina's (van-tot) | 1086-1090 |
Aantal pagina's | 5 |
Tijdschrift | European Neuropsychopharmacology |
Volume | 24 |
Nummer van het tijdschrift | 7 |
DOI's | |
Status | Published - jul.-2014 |
Extern gepubliceerd | Ja |