The transport of integral membrane proteins across the nuclear pore complex

Anne C. Meinema, Bert Poolman, Liesbeth M. Veenhoff*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

10 Citaten (Scopus)

Samenvatting

The nuclear envelope protects and organizes the genome. The nuclear pore complexes embedded in the nuclear envelope allow selective transport of macromolecules between the cytosol and nucleoplasm, and as such help to control the flow of information from DNA to RNA to proteins. A growing list of integral membrane proteins of the nuclear envelope are described to function in the organization of the genome, as well as the assembly of the NPCs. Here, we discuss how the nuclear pore complex may sort these proteins to obtain a specific protein composition of the inner membrane.

Originele taal-2English
Pagina's (van-tot)322-329
Aantal pagina's8
TijdschriftNucleus-Austin
Volume3
Nummer van het tijdschrift4
DOI's
StatusPublished - 2012

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