The use of plant cell cultures for the production of podophyllotoxin and related lignans

U Empt*, AW Alfermann, N Pras, M Petersen

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    48 Citaten (Scopus)


    Podophyllotoxin isolated from rhizomes of Podophyllum plants (Podophyllaceae) serves as precursor for the semi-synthesis of anticancer therapeutics. The plants are collected from the wild and are becoming threatened species due to overcollection. Suspension cultures of Linum album (Linaceae) accumulate podophyllotoxin as well and could therefore serve as an alternative source for this important aryltetralin lactone lignan. The culture characteristics of suspension cultures of Linum album are reported in the paper. The fast growth of the cell culture and a podophyllotoxin accumulation of about 0.2% of the cell dry weight would enable a podophyllotoxin production of ca. 28 mg in 11 days in one liter of suspension culture.

    Originele taal-2English
    Pagina's (van-tot)145-150
    Aantal pagina's6
    TijdschriftJournal of applied botany-Angewandte botanik
    Nummer van het tijdschrift3-4
    StatusPublished - sep-2000
    EvenementSymposium Secondary Plant Compounds of the Vereinigung-fur-Angewandte-Botanik in conjunction with section Natural Plant Compounds of the Deutsche-Botanishce-Gesellschaft - , Germany
    Duur: 30-sep-19992-okt-1999

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