The validity of circulating microRNAs in oncology: five years of challenges and contradictions

J Jarry, D Schadendorf, C Greenwood, A Spatz, L C van Kempen*

*Corresponding author voor dit werk

Onderzoeksoutput: Review articlepeer review

142 Citaten (Scopus)
105 Downloads (Pure)

Samenvatting

MicroRNAs (miRNAs) in circulation have received an increasing amount of interest as potential minimal invasive diagnostic tools in oncology. Several diagnostic, prognostic and predictive signatures have been proposed for a variety of cancers at different stages of disease, but these have not been subjected to a critical review regarding their validity: reproducible identification in comparable studies and/or with different platforms of miRNA detection. In this review, we will critically address the results of circulating miRNA research in oncology that have been published between January 2008 and June 2013 (5.5 years), and discuss pre-analytical challenges, technological pitfalls and limitations that may contribute to the non-reproducibility of circulating miRNA research.

Originele taal-2English
Pagina's (van-tot)819-829
Aantal pagina's11
TijdschriftMolecular oncology
Volume8
Nummer van het tijdschrift4
DOI's
StatusPublished - jun.-2014
Extern gepubliceerdJa

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