TY - BOOK
T1 - Therapeutic immunization strategies against cervical cancer
T2 - induction of cell-mediated immunity in murine models
AU - Bungener, Laura Barbara
N1 - date_submitted:2004
Rights: University of Groningen
PY - 2004
Y1 - 2004
N2 - The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated.
AB - The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated.
KW - 44.92 gynaecologie en obstetrie
KW - Proefschriften (vorm)
KW - Baarmoederhalskanker, Immuunreacties, Therapieën
M3 - Thesis fully internal (DIV)
SN - 9064643040
PB - s.n.
ER -