Three-dimensional cross-linked F-actin networks: Relation between network architecture and mechanical behavior

E. M. Huisman*, T. van Dillen, P. R. Onck, E. Van der Giessen

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

147 Citaten (Scopus)
338 Downloads (Pure)


Numerical simulations are reported for the response of three-dimensional cross-linked F-actin networks when subjected to large deformations. In addition to the physiological parameters such as actin and cross-linker concentration, the model explicitly accounts for filament properties and network architecture. Complementary to two-dimensional studies, we find that the strain-stiffening characteristics depend on network architecture through the local topology around cross-links.

Originele taal-2English
Aantal pagina's4
TijdschriftPhysical Review Letters
Nummer van het tijdschrift20
StatusPublished - 16-nov.-2007

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