Drawing on immigrant adaptation and life course perspectives, this study explores reasons for differences in the timing of young adults' departure from the parental home. We extend existing research by examining: (a) associations between home-leaving, and immigrant generation and parental region of origin, and (b) the role of parental language use in the home as a moderator of these associations. Using data from the National Longitudinal Survey of Youth 1997 (N = 5,994), we used Cox proportional hazard regressions to estimate the risk of home-leaving. Results revealed that 3+ generation immigrants are most likely to leave home, followed by second, 1.75, and 1.5 generation. Youth whose parents were from Latin America were least likely to leave compared with those with parents from other regions. Parental language spoken at home is a moderator such that, net of controls, youth with Latin American parents are less likely to leave the parental home than those with U.S.-born parents when their parents speak a language other than English at home. Findings contribute to the immigration literature by examining nuanced differences among immigrants of different generations and origins, and pointing to multiple factors that contribute to differences in the timing of the transition out of the parental home.