TldR: TnpB’s evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators

Prarthana Mohanraju; Wen Y. Wu

doi:10.1016/j.tim.2024.09.004

TldR: TnpB’s evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators

Prarthana Mohanraju^*, Wen Y. Wu^*

^*Corresponding author voor dit werk

Chemische en Farmaceutische Biologie

Onderzoeksoutput: Article › Academic › peer review

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TnpB proteins are transposon-encoded nucleases involved in transposon DNA propagation. Wiegand et al. identified a new class of TnpB-derived proteins, called TnpB-like nuclease-dead repressors (TldRs), which function as RNA-guided transcriptional regulators targeting conserved promoter regions. In Enterobacteriaceae, bacteriophages use TldRs and an adjacent phage gene to modulate host flagellar assembly.

Originele taal-2	English
Pagina's (van-tot)	1039-1041
Aantal pagina's	3
Tijdschrift	Trends in Microbiology
Volume	32
Nummer van het tijdschrift	11
Vroegere onlinedatum	19-sep.-2024
DOI's	https://doi.org/10.1016/j.tim.2024.09.004
Status	Published - nov.-2024

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10.1016/j.tim.2024.09.004

TldR: TnpB’s evolutionary shift from transposon nucleases to RNA-guided transcriptional regulatorsFinal publisher's version, 573 KBLicentie: Taverne

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title = "TldR: TnpB{\textquoteright}s evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators",

abstract = "TnpB proteins are transposon-encoded nucleases involved in transposon DNA propagation. Wiegand et al. identified a new class of TnpB-derived proteins, called TnpB-like nuclease-dead repressors (TldRs), which function as RNA-guided transcriptional regulators targeting conserved promoter regions. In Enterobacteriaceae, bacteriophages use TldRs and an adjacent phage gene to modulate host flagellar assembly.",

author = "Prarthana Mohanraju and Wu, \{Wen Y.\}",

year = "2024",

month = nov,

doi = "10.1016/j.tim.2024.09.004",

language = "English",

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journal = "Trends in Microbiology",

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AU - Mohanraju, Prarthana

AU - Wu, Wen Y.

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Y1 - 2024/11

N2 - TnpB proteins are transposon-encoded nucleases involved in transposon DNA propagation. Wiegand et al. identified a new class of TnpB-derived proteins, called TnpB-like nuclease-dead repressors (TldRs), which function as RNA-guided transcriptional regulators targeting conserved promoter regions. In Enterobacteriaceae, bacteriophages use TldRs and an adjacent phage gene to modulate host flagellar assembly.

AB - TnpB proteins are transposon-encoded nucleases involved in transposon DNA propagation. Wiegand et al. identified a new class of TnpB-derived proteins, called TnpB-like nuclease-dead repressors (TldRs), which function as RNA-guided transcriptional regulators targeting conserved promoter regions. In Enterobacteriaceae, bacteriophages use TldRs and an adjacent phage gene to modulate host flagellar assembly.

U2 - 10.1016/j.tim.2024.09.004

DO - 10.1016/j.tim.2024.09.004

M3 - Article

SN - 0966-842X

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JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 11

ER -

TldR: TnpB’s evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators

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