Toll-like receptors in the pathogenesis of human B cell malignancies

Johana M. Isaza-Correa, Zheng Liang, Anke van den Berg, Arjan Diepstra, Lydia Visser*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

31 Citaten (Scopus)
343 Downloads (Pure)

Samenvatting

Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of their ligands, leads to aberrant responses in the malignant B-cells. According to current data, TLRs can be implicated in malignant transformation, tumor progression and immune evasion processes. Most of the studies focused on multiple myeloma and chronic lymphocytic leukemia, but in the last decade the putative role of TLRs in other types of B-cell lymphomas has gained much interest. The aim of this review is to discuss recent findings on the role of TLRs in normal B cell functioning and their role in the pathogenesis of B-cell malignancies.

Originele taal-2English
Artikelnummer57
Aantal pagina's10
TijdschriftJournal of Hematology & Oncology
Volume7
Nummer van het tijdschrift1
DOI's
StatusPublished - 12-aug-2014

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