Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

Lu Ge

doi:10.33612/diss.146106454

Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

Lu Ge

Onderzoeksoutput: Thesis fully internal (DIV)

403 Downloads (Pure)

Samenvatting

Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	van Rijn, Patrick, Supervisor van Kooten, Theo, Co-supervisor
Datum van toekenning	7-dec.-2020
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
DOI's	https://doi.org/10.33612/diss.146106454
Status	Published - 2020

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10.33612/diss.146106454

Title and contentsFinal publisher's version, 373 KB
Chapter 1Final publisher's version, 1,19 MB
Chapter 2Final publisher's version, 1,81 MB
Chapter 3Final publisher's version, 2,37 MB
Chapter 4Final publisher's version, 1,35 MB
Chapter 5Final publisher's version, 1,52 MB
Chapter 6Final publisher's version, 1,09 MB
SummaryFinal publisher's version, 182 KB
SamenvattingFinal publisher's version, 341 KB
Complete thesisFinal publisher's version, 8,21 MB
PropositionsFinal publisher's version, 106 KB

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AB - Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.

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