Samenvatting
It has been proposed that the bitopic membrane protein SecG undergoes topology inversion during translocation of (pre)proteins via SecYEG. Here we show that SecG covalently cross-linked to SecY cannot invert its topology while remaining fully functional in protein translocation. Our results strongly disfavor topology inversion of SecG during protein translocation.
Originele taal-2 | English |
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Pagina's (van-tot) | 1188-1190 |
Aantal pagina's | 3 |
Tijdschrift | Journal of Bacteriology |
Volume | 188 |
Nummer van het tijdschrift | 3 |
DOI's | |
Status | Published - feb.-2006 |