TY - JOUR
T1 - Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
AU - van Praagh, Gijs D
AU - Nienhuis, Pieter H
AU - de Jong, Daniel M
AU - Reijrink, Melanie
AU - van der Geest, Kornelis S M
AU - Brouwer, Elisabeth
AU - Glaudemans, Andor W.J.M.
AU - Sinha, Bhanu
AU - Willemsen, Antoon T.M.
AU - Slart, Riemer H.J.A.
PY - 2021/11
Y1 - 2021/11
N2 - The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Significantly higher SUVs were found in women compared with men, whereas SULs were similar between sexes. In addition, higher fat mass was associated with increased SUVs (r = 0.56 to 0.65; all p < 0.001) in the blood pool, but no correlations were found between SULs and fat mass (r = -0.25 to -0.15; all p > 0.05). Lower eGFR was associated with a higher FDG blood pool activity for all uptake values. In FDG-PET/CT studies with LVV patients, we recommend using SUL over SUV, while caution is advised in interpreting SUV and SUL measures when patients have impaired kidney function.
AB - The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Significantly higher SUVs were found in women compared with men, whereas SULs were similar between sexes. In addition, higher fat mass was associated with increased SUVs (r = 0.56 to 0.65; all p < 0.001) in the blood pool, but no correlations were found between SULs and fat mass (r = -0.25 to -0.15; all p > 0.05). Lower eGFR was associated with a higher FDG blood pool activity for all uptake values. In FDG-PET/CT studies with LVV patients, we recommend using SUL over SUV, while caution is advised in interpreting SUV and SUL measures when patients have impaired kidney function.
KW - vasculitis
KW - fluorodeoxyglucose F18
KW - Positron emission tomography computed tomography
KW - Standardized uptake values
KW - lean body mass
U2 - 10.3390/diagnostics11111986
DO - 10.3390/diagnostics11111986
M3 - Article
C2 - 34829332
SN - 2075-4418
VL - 11
JO - Diagnostics
JF - Diagnostics
IS - 11
M1 - 1986
ER -