TRAIL-induced apoptosis in colon cancer: resistance and modulation

Caroline Mirjam Maria van Geelen



    Colorectal cancer is one of the most important causes of cancer-related death. Although over 80% of colorectal carcinomas are macroscopically resectable at the time of diagnosis, 50% of patients subsequently relapse with metastatic disease, due to the presence of micrometastasis. Adjuvant chemotherapy for patients who had local tumor lymph node involvement aims to eliminate minimal residual tumor cells and increase the proportion of patients achieving long-term diseasefree and overall survival. However, intrinsic as well as acquired resistance to chemotherapeutic drugs remains a major problem in the treatment of this disease. Zie: Summary
    Originele taal-2Arabic
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    • de Vries, Liesbeth, Supervisor
    Datum van toekenning27-apr-2005
    Plaats van publicatieGroningen
    Gedrukte ISBN's9036722578
    StatusPublished - 2005

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