Transient impairment of the adaptive response to fasting in FXR-deficient mice

B Cariou, K van Harmelen, D Duran-Sandoval, T van Dijk, A Grefhorst, E Bouchaert, JC Fruchart, FJ Gonzalez, F Kuipers, B Staels*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

72 Citaten (Scopus)


The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Originele taal-2English
Pagina's (van-tot)4076-4080
Aantal pagina's5
TijdschriftFEBS Letters
Nummer van het tijdschrift19
StatusPublished - 1-aug-2005

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