Transient impairment of the adaptive response to fasting in FXR-deficient mice

B Cariou; K van Harmelen; D Duran-Sandoval; T van Dijk; A Grefhorst; E Bouchaert; JC Fruchart; FJ Gonzalez; F Kuipers; B Staels

doi:10.1016/j.febslet.2005.06.033

Transient impairment of the adaptive response to fasting in FXR-deficient mice

B Cariou, K van Harmelen, D Duran-Sandoval, T van Dijk, A Grefhorst, E Bouchaert, JC Fruchart, FJ Gonzalez, F Kuipers, B Staels^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

75 Citaten (Scopus)

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The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

Originele taal-2	English
Pagina's (van-tot)	4076-4080
Aantal pagina's	5
Tijdschrift	FEBS Letters
Volume	579
Nummer van het tijdschrift	19
DOI's	https://doi.org/10.1016/j.febslet.2005.06.033
Status	Published - 1-aug.-2005

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@article{0faf52acba0f4df0b45a40f476cb4df4,

title = "Transient impairment of the adaptive response to fasting in FXR-deficient mice",

abstract = "The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.",

keywords = "farnesoid X receptor, fasting, PEPCK, gluconeogenesis, FARNESOID-X-RECEPTOR, PHOSPHOENOLPYRUVATE CARBOXYKINASE, BILE-ACIDS, METABOLISM, LIVER, GLUCONEOGENESIS, HOMEOSTASIS, INHIBITION, EXPRESSION, CYCLE",

author = "B Cariou and {van Harmelen}, K and D Duran-Sandoval and {van Dijk}, T and A Grefhorst and E Bouchaert and JC Fruchart and FJ Gonzalez and F Kuipers and B Staels",

year = "2005",

month = aug,

day = "1",

doi = "10.1016/j.febslet.2005.06.033",

language = "English",

volume = "579",

pages = "4076--4080",

journal = "FEBS Letters",

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number = "19",

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T1 - Transient impairment of the adaptive response to fasting in FXR-deficient mice

AU - Cariou, B

AU - van Harmelen, K

AU - Duran-Sandoval, D

AU - van Dijk, T

AU - Grefhorst, A

AU - Bouchaert, E

AU - Fruchart, JC

AU - Gonzalez, FJ

AU - Kuipers, F

AU - Staels, B

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

AB - The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

KW - farnesoid X receptor

KW - fasting

KW - PEPCK

KW - gluconeogenesis

KW - FARNESOID-X-RECEPTOR

KW - PHOSPHOENOLPYRUVATE CARBOXYKINASE

KW - BILE-ACIDS

KW - METABOLISM

KW - LIVER

KW - GLUCONEOGENESIS

KW - HOMEOSTASIS

KW - INHIBITION

KW - EXPRESSION

KW - CYCLE

U2 - 10.1016/j.febslet.2005.06.033

DO - 10.1016/j.febslet.2005.06.033

M3 - Article

SN - 0014-5793

VL - 579

SP - 4076

EP - 4080

JO - FEBS Letters

JF - FEBS Letters

IS - 19

ER -

Transient impairment of the adaptive response to fasting in FXR-deficient mice

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