Transition from stress sensitivity to a depressive state: longitudinal twin study

Marieke Wichers*, Nicole Geschwind, Nele Jacobs, Gunter Kenis, Frenk Peeters, Catherine Derom, Evert Thiery, Philippe Delespaul, Jim van Os

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

90 Citaten (Scopus)



Daily-life stress sensitivity is associated with depression, but prospective data are lacking.


To examine associations between baseline ecological daily-life stress sensitivity and later depression, and to identify genetic and non-genetic factors moderating the transition from stress sensitivity to depression.


Daily-life stress sensitivity was assessed at baseline in twins (n = 502). one baseline and four follow-up measurements of depressive symptoms and negative life events were collected, as well as interview-based diagnoses at baseline and last follow-up. Hypothesised genetic markers were determined.


Baseline stress sensitivity was associated with increased depressive symptoms at follow-up and risk of major depressive disorder. Both genetic liability and major life events moderated the probability of transition from stress sensitivity to depression.


Onset of depression is attributable to pre-onset ecological measurements of stress sensitivity, particularly where genetic liability is high and individuals have reached a stage where the influence of competing environmental causes is low.

Originele taal-2English
Pagina's (van-tot)498-503
Aantal pagina's6
TijdschriftThe British Journal of Psychiatry
Nummer van het tijdschrift6
StatusPublished - dec-2009
Extern gepubliceerdJa

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