Tremor in multiple sclerosis

Marcus Koch*, Jop Mostert, Dorothea Heersema, Jacques De Keyser

*Bijbehorende auteur voor dit werk

    Onderzoeksoutput: Review articleAcademicpeer review

    117 Citaten (Scopus)


    Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be severely disabling and embarrassing for patients, is difficult to manage. Isoniazid in high doses, carbamazepine, propranolol and gluthetimide have been reported to provide some relief, but published evidence of effectiveness is very limited. Most trials were of small size and of short duration. Cannabinoids appear ineffective. Tremor reduction can be obtained with stereotactic thalamotomy or thalamic stimulation. However, the studies were small and information on long-term functional outcome is scarce. Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research.

    Originele taal-2English
    Pagina's (van-tot)133-145
    Aantal pagina's13
    TijdschriftJournal of Neurology
    Nummer van het tijdschrift2
    StatusPublished - feb-2007

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