Trimetazidine Reduces Endogenous Free Fatty Acid Oxidation and Improves Myocardial Efficiency in Obese Humans

Marco Bucci, Ronald Borra, Kjell Nagren, Jussi P. Parkka, Silvia Del Ry, Romina Maggio, Helena Tuunanen, Tapio Viljanen, Manuela Cabiati, Sara Rigazio, Markku Taittonen, Uberto Pagotto, Riitta Parkkola, Lionel H. Opie, Pirjo Nuutila, Juhani Knuuti, Patricia Iozzo*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

42 Citaten (Scopus)

Samenvatting

Introduction: The metabolic modulator trimetazidine (TMZ) has been suggested to induce a metabolic shift from myocardial fatty acid oxidation (FAO) to glucose utilization, but this mechanism remains unproven in humans. The oxidation of plasma derived FA is commonly measured in humans, whereas the contribution of FA from triglycerides stored in the myocardium has been poorly characterized. Aims: To verify the hypothesis that TMZ induces a metabolic shift, we combined positron emission tomography (PET) and magnetic resonance spectroscopy (H-1-MRS) to measure myocardial FAO from plasma and intracellular lipids, and myocardial glucose metabolism. Nine obese subjects were studied before and after 1 month of TMZ treatment. Myocardial glucose and FA metabolism were assessed by PET with F-18-fluorodeoxyglucose and C-11-palmitate. H-1-MRS was used to measure myocardial lipids, the latter being integrated into the PET data analysis to quantify myocardial triglyceride turnover. Results: Myocardial FAO derived from intracellular lipids was at least equal to that of plasma FAs (P= NS). BMI and cardiac work were positively associated with the oxidation of plasma derived FA (P

Originele taal-2English
Pagina's (van-tot)333-341
Aantal pagina's9
TijdschriftCardiovascular therapeutics
Volume30
Nummer van het tijdschrift6
DOI's
StatusPublished - 2012
Extern gepubliceerdJa

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