Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis

Ting Zhao; Andre Boltjes; Eberhardt Herdtweck; Alexander Doemling

doi:10.1021/ol303348m

Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis

Ting Zhao, Andre Boltjes, Eberhardt Herdtweck, Alexander Doemling^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

47 Citaten (Scopus)

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The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.

Originele taal-2	English
Pagina's (van-tot)	639-641
Aantal pagina's	3
Tijdschrift	Organic letters
Volume	15
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1021/ol303348m
Status	Published - 1-feb.-2013

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Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis
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CCDC 903083: Experimental Crystal Structure Determination
Zhao, T. (Contributor), Boltjes, A. (Contributor), Herdtweck, E. (Contributor) & Dömling, A. (Contributor), University of Groningen, 26-sep.-2012
DOI: 10.5517/ccz9qqp
Dataset
CCDC 1950909: Experimental Crystal Structure Determination
Zhao, T. (Contributor), Boltjes, A. (Contributor), Herdtweck, E. (Contributor) & Dömling, A. (Contributor), University of Groningen, 2-sep.-2019
DOI: 10.5517/ccdc.csd.cc23h2k8
Dataset
CCDC 903084: Experimental Crystal Structure Determination
Zhao, T. (Contributor), Boltjes, A. (Contributor), Herdtweck, E. (Contributor) & Dömling, A. (Contributor), University of Groningen, 26-sep.-2012
DOI: 10.5517/ccz9qrq
Dataset

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abstract = "The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.",

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AU - Zhao, Ting

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AU - Herdtweck, Eberhardt

AU - Doemling, Alexander

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.

AB - The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.

KW - 4-COMPONENT REACTION

KW - DERIVATIVES

KW - ACID

U2 - 10.1021/ol303348m

DO - 10.1021/ol303348m

M3 - Article

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JO - Org.Lett.

JF - Org.Lett.

IS - 3

ER -

Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis

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Datasets

CCDC 903083: Experimental Crystal Structure Determination

CCDC 1950909: Experimental Crystal Structure Determination

CCDC 903084: Experimental Crystal Structure Determination

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