Two-month-old infants at risk for dyslexia do not discriminate /bAk/ from /dAk/: A brain-mapping study

Theo van Leeuwen*, Pieter Been, Marieke van Herten, Frans Zwarts, Ben Maassen, Aryan van der Leij

*Bijbehorende auteur voor dit werk

    Onderzoeksoutput: ArticleAcademicpeer review

    24 Citaten (Scopus)


    Dyslexics have problems with categorization of speech sounds, in particular when rapid temporal processing is involved such as in formant transitions of stop-consonants. Infants are already sensitive to such auditory features, but here we show that precursors of impaired categorization are already present in the brain responses of two-month-old infants at familial risk for dyslexia. Natural speech stimuli (/bAk/ and /dAk/), at either side of the phoneme boundary, induced multiple mismatch responses in control infants tinder pre-attentive and pre-cognitive conditions. Infants at-risk showed an attenuated early mismatch response and an absent late one, in addition to diminished cortical activity in the left hemisphere. These results are consistent with a temporal processing deficit in the infants at risk and may point to an early precursor of the disorder. (C) 2007 Published by Elsevier Ltd.

    Originele taal-2English
    Pagina's (van-tot)333-348
    Aantal pagina's16
    TijdschriftJournal of Neurolinguistics
    Nummer van het tijdschrift4
    StatusPublished - jul.-2008

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