Ubiquinol Improves Symptoms in Children with Autism

Anna Gvozdjakova*, Jarmila Kucharska, Daniela Ostatnikova, Katarina Babinska, Dalibor Nakladal, Fred L. Crane

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    41 Citaten (Scopus)
    371 Downloads (Pure)

    Samenvatting

    Background. Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and agression) and sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress and antioxidants can participate in pathobiochemical mechanisms of autism. Methods. Twenty-four children, aged 3-6 years, with autism according to the DSM IV criteria and using CARS were included in the study. Concentrations of CoQ(10-TOTAL), gamma- and alpha-tocopherol, beta-carotene, and lipid peroxidation were determined in plasma before and after three months of supportive therapy with ubiquinol at a daily dose 2 x 50 mg. Data on behavior of the children were collected from parents at the same time. Results. Ubiquinol supportive therapy improved symptoms in children with autism, as communication with parents (in 12%), verbal communication (in 21%), playing games of children (in 42%), sleeping (in 34%), and food rejection (in 17%), with CoQ(10-TOTAL) plasma level above 2.5 mu mol/L. Conclusions. Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ(10-TOTAL) and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.

    Originele taal-2English
    Artikelnummer798957
    Aantal pagina's6
    TijdschriftOxidative Medicine and Cellular Longevity
    Volume2014
    DOI's
    StatusPublished - 2014

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