Unlocking New Reactivities in Enzymes by Iminium Catalysis

Guangcai Xu, Gerrit J. Poelarends*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

7 Citaten (Scopus)
25 Downloads (Pure)

Samenvatting

The application of biocatalysis in conquering challenging synthesis requires the constant input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from synthetic chemistry has yielded fruitful new-to-nature enzymes. Organocatalysis was originally bio-inspired and has become the third pillar of asymmetric catalysis. Transferring organocatalytic reactions back to enzyme platforms is a promising approach for biocatalyst creation. Herein, we summarize recent developments in the design of novel biocatalysts that adopt iminium catalysis, a fundamental branch in organocatalysis. By repurposing existing enzymes or constructing artificial enzymes, various biocatalysts for iminium catalysis have been created and optimized via protein engineering to promote valuable abiological transformations. Recent advances in iminium biocatalysis illustrate the power of combining chemomimetic biocatalyst design and directed evolution to generate useful new-to-nature enzymes.

Originele taal-2English
Artikelnummere202203613
Aantal pagina's14
TijdschriftAngewandte Chemie - International Edition
Volume61
Nummer van het tijdschrift30
Vroegere onlinedatum7-mei-2022
DOI's
StatusPublished - 25-jul.-2022

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