Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Paul D Kruithof; Sergey Lunev; Sheila P Aguilar Lozano; Fernando de Assis Batista; Zayana M Al-Dahmani; Jaap A Joles; Amalia M Dolga; Matthew R Groves; Harry van Goor

doi:10.1016/j.bbadis.2020.165716

Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Paul D Kruithof, Sergey Lunev, Sheila P Aguilar Lozano, Fernando de Assis Batista, Zayana M Al-Dahmani, Jaap A Joles, Amalia M Dolga, Matthew R Groves, Harry van Goor^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review article › peer review

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Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron-sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

Originele taal-2	English
Artikelnummer	165716
Aantal pagina's	8
Tijdschrift	Biochimica et biophysica acta-Molecular basis of disease
Volume	1866
Nummer van het tijdschrift	6
Vroegere onlinedatum	12-feb.-2020
DOI's	https://doi.org/10.1016/j.bbadis.2020.165716
Status	Published - 1-jun.-2020

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10.1016/j.bbadis.2020.165716Licentie: CC BY

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@article{7ff5885485e8443cb508ebde94a8d336,

title = "Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases",

abstract = "Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron-sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.",

keywords = "Sulfurtransferase, TST, Rhodanese, Diabetes, Obesity, Antioxidant systems, THIOREDOXIN-INTERACTING PROTEIN, NF-KAPPA-B, HYDROGEN-SULFIDE, ACTIVE-SITE, SUBCELLULAR-DISTRIBUTION, MERCAPTOPYRUVATE SULFURTRANSFERASE, MITOCHONDRIAL RHODANESE, SUBSTITUTED RHODANESE, SULFUR TRANSFER, ENZYME",

author = "Kruithof, {Paul D} and Sergey Lunev and {Aguilar Lozano}, {Sheila P} and {de Assis Batista}, Fernando and Al-Dahmani, {Zayana M} and Joles, {Jaap A} and Dolga, {Amalia M} and Groves, {Matthew R} and {van Goor}, Harry",

note = "Copyright {\textcopyright} 2020. Published by Elsevier B.V.",

year = "2020",

month = jun,

day = "1",

doi = "10.1016/j.bbadis.2020.165716",

language = "English",

volume = "1866",

journal = "Biochimica et biophysica acta-Molecular basis of disease",

issn = "0925-4439",

publisher = "ELSEVIER SCIENCE BV",

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TY - JOUR

T1 - Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

AU - Kruithof, Paul D

AU - Lunev, Sergey

AU - Aguilar Lozano, Sheila P

AU - de Assis Batista, Fernando

AU - Al-Dahmani, Zayana M

AU - Joles, Jaap A

AU - Dolga, Amalia M

AU - Groves, Matthew R

AU - van Goor, Harry

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron-sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

AB - Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron-sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

KW - Sulfurtransferase

KW - TST

KW - Rhodanese

KW - Diabetes

KW - Obesity

KW - Antioxidant systems

KW - THIOREDOXIN-INTERACTING PROTEIN

KW - NF-KAPPA-B

KW - HYDROGEN-SULFIDE

KW - ACTIVE-SITE

KW - SUBCELLULAR-DISTRIBUTION

KW - MERCAPTOPYRUVATE SULFURTRANSFERASE

KW - MITOCHONDRIAL RHODANESE

KW - SUBSTITUTED RHODANESE

KW - SULFUR TRANSFER

KW - ENZYME

U2 - 10.1016/j.bbadis.2020.165716

DO - 10.1016/j.bbadis.2020.165716

M3 - Review article

C2 - 32061776

SN - 0925-4439

VL - 1866

JO - Biochimica et biophysica acta-Molecular basis of disease

JF - Biochimica et biophysica acta-Molecular basis of disease

IS - 6

M1 - 165716

ER -