Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Paul D Kruithof, Sergey Lunev, Sheila P Aguilar Lozano, Fernando de Assis Batista, Zayana M Al-Dahmani, Jaap A Joles, Amalia M Dolga, Matthew R Groves, Harry van Goor*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

24 Citaten (Scopus)
257 Downloads (Pure)


Thiosulfate sulfurtransferase (TST, EC, also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron-sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

Originele taal-2English
Aantal pagina's8
TijdschriftBiochimica et biophysica acta-Molecular basis of disease
Nummer van het tijdschrift6
Vroegere onlinedatum12-feb.-2020
StatusPublished - 1-jun.-2020

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