@article{988b2b534d17495dbb1350be3978e2bc,
title = "Use of fractional exhaled nitric oxide to guide the treatment of asthma an official american thoracic society clinical practice guideline",
abstract = "Background: The fractional exhaled nitric oxide (FENO) test is a point-of-care test that is used in the assessment of asthma.Objective: To provide evidence-based clinical guidance on whether FENO testing is indicated to optimize asthma treatment in patients with asthma in whom treatment is being considered.Methods: An international, multidisciplinary panel of experts was convened to form a consensus document regarding a single question relevant to the use of FENO. The question was selected from three potential questions based on the greatest perceived impact on clinical practice and the unmet need for evidencebased answers related to this question. The panel performed systematic reviews of published randomized controlled trials between 2004 and 2019 and followed the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence-to-decision framework to develop recommendations. All panel members evaluated and approved the recommendations.Main Results: After considering the overall low quality of the evidence, the panel made a conditional recommendation for FENO-based care. In patients with asthma in whom treatment is being considered, we suggest that FENO is beneficial and should be used in addition to usual care. This judgment is based on a balance of effects that probably favors the intervention; the moderate costs and availability of resources, which probably favors the intervention; and the perceived acceptability and feasibility of the intervention in daily practice.Conclusions: Clinicians should consider this recommendation to measure FENO in patients with asthma in whom treatment is being considered based on current best available evidence. ",
keywords = "Airway disease, Asthma, Inhaled steroids, Nitric oxide, Type 2 inflammation",
author = "Khatri, {Sumita B.} and Iaccarino, {Jonathan M.} and Amisha Barochia and Israa Soghier and Praveen Akuthota and Anna Brady and Covar, {Ronina A.} and Debley, {Jason S.} and Zuzana Diamant and Fitzpatrick, {Anne M.} and Kaminsky, {David A.} and Kenyon, {Nicholas J.} and Sandhya Khurana and Lipworth, {Brian J.} and Kevin McCarthy and Michael Peters and Que, {Loretta G.} and Ross, {Kristie R.} and Schneider-Futschik, {Elena K.} and Sorkness, {Christine A.} and Hallstrand, {Teal S.}",
note = "Funding Information: WebMD, MJH Life Sciences, Prime CME, Projects in Knowledge, Rockpointe, and Vindico CME; received research support from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, NIH, Novartis, and Regeneron; and received royalties from UpToDate. R.A.C. served as a consultant for Cohero Health; and received research support from the American Lung Association ACRC, Avillion, GlaxoSmithKline, and NHLBI. Z.D. served as a speaker for Sanofi. D.A.K. served as a consultant for Spiration; served on a data and safety monitoring board for Acorda; and served as a speaker for MGC Pharmaceuticals. S.K. received research support from GlaxoSmithKline and Sanofi; and provided writing support for Boehringer Ingelheim. B.J.L. served on an advisory committee for AstraZeneca, Chiesi, Circassia, Novartis, Sanofi, and Teva; served as a consultant for AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Circassia, Genentech, Lupin, Sanofi, Teva, and Vectura; served as a speaker for AstraZeneca, Boehringer Ingelheim, Chiesi, Circassia, Sanofi, Teva, and Thorasys; received research support from AstraZeneca, Boehringer Ingelheim, Chiesi, Sanofi, and Teva; received travel support from AstraZeneca, Chiesi, and Teva; and received equipment from GlaxoSmithKline and Thorasys. S.B.K., T.S.H., A. Barochia, A. Brady, J.S.D., A.M.F., J.M.I., N.J.K., K.M., M.P., L.G.Q., K.R.R., E.K.S.-F., I.S., and C.A.S. reported no commercial or relevant noncommercial interests. Funding Information: Supported by the American Thoracic Society. Publisher Copyright: {\textcopyright} 2021 by the American Thoracic Society.",
year = "2021",
month = nov,
day = "15",
doi = "10.1164/rccm.202109-2093ST",
language = "English",
volume = "204",
pages = "e97--e109",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "AMER THORACIC SOC",
number = "10",
}