Use of real-world evidence in pharmacoeconomic analysis: illustrations in The Netherlands and China

Yunyu Huang

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    Samenvatting

    The main objective of the thesis is to assess the added value of use of observational data in pharmacoeconomic (PE) evaluations. Five sub-aims were addressed in the thesis:
    1) a systematic literature review summarized results evidencing the cost-saving potentials of renin-angiotensin-aldosterone system (RAAS) inhibitors, including angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs), in type 2 diabetes (T2D) patients with nephropathy compared with conventional therapy excluding a RAAS inhibitor;
    2) a general framework was developed to illustrate the problems and solutions of data quality assessment and preprocessing, based on the ‘fit-for-use’ concept;
    3) a comparative effectiveness study compared the effectiveness of ACE inhibitors vs. ARBs for protecting T2D patients from renal function decline in a real-world setting, the value of observational data in outcomes research studies was assessed;
    4) a real-world study described the changes of diabetes cost in Chinese patients using electronic claims data, and the value of observational data in health economics studies was assessed;
    5) a cost-effectiveness analysis of RAAS inhibitors (ACE inhibitors and ARBs) vs. other active anti-hypertensive agents and no anti-hypertensive treatment in patients with T2D and nephropathy in China was performed from a healthcare payer perspective, and a budget impact analysis was conducted alongside the PE evaluation to analyze the budget changes of Chinese urban employee basic medical insurance (UEBMI) when different strategies of medication use are applied; the use of observational data in PE evaluations was assessed.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    Begeleider(s)/adviseur
    • Haaijer-Ruskamp, Floor, Supervisor
    • Postma, Maarten, Supervisor
    • Vemer, Pepijn, Co-supervisor
    Datum van toekenning16-sep.-2019
    Plaats van publicatie[Groningen]
    Uitgever
    Gedrukte ISBN's978-94-034-1870-4
    Elektronische ISBN's978-94-034-1869-8
    DOI's
    StatusPublished - 2019

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