Validation of a Transcutaneous CO2 Monitor in Adult Patients with Chronic Respiratory Failure

A. Hazenberg*, J. G. Zijlstra, H. A. M. Kerstjens, P. J. Wijkstra

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

24 Citaten (Scopus)


Background: Home mechanical ventilation is usually started in hospital as arterial blood gas sampling is deemed necessary to monitor CO2 and O-2 adequately during institution of ventilatory support. A non-invasive device to reliably measure CO2 transcutaneously would alleviate the need for high care settings for measurement and open the possibility for home registration. Objectives: In this study we investigated whether the TOSCA (R) transcutaneous CO2 (PtcCO(2)) measurements, performed continuously during the night, reliably reflect arterial CO2 (PaCO2) measurements in adults with chronic respiratory failure. Methods: Paired measurements were taken in 15 patients hospitalised to evaluate their blood gas exchange. Outcomes were compared 30 min, 2, 4, 6 and 8 h after attaching the sensor to the earlobe. A maximum difference of 1.0 kPa and 95% limits of agreement (LOA) of 1 kPa between CO2 pressure measurements, following the analysis by Bland and Altman, were determined as acceptable. Results: Mean PtcCO(2) was 0.4 kPa higher (LOA -0.48 to 1.27 kPa) than mean PaCO2 after 30 min. These figures were 0.6 kPa higher (LOA -0.60 to 1.80 kPa) after 4 h, with a maximum of 0.72 kPa (LOA 0.35 to 1.79 kPa) after 8 h. The corresponding values for changes in PtcCO(2) versus PaCO2 were not significant (ANOVA). Conclusions: PtcCO(2) measurement, using TOSCA, is a valid method showing an acceptable agreement with PaCO2 during 8 h of continuous measurement. Therefore, this device can be used to monitor CO2 adequately during chronic ventilatory support. Copyright (C) 2011 S. Karger AG, Basel

Originele taal-2English
Pagina's (van-tot)242-246
Aantal pagina's5
Nummer van het tijdschrift3
StatusPublished - 2011


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