Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

George P. Liao; Eman M. M. Abdelraheem; Constantinos G. Neochoritis; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; David C. McGowan; Alexander Dömling

doi:10.1021/acs.orglett.5b02419

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

George P. Liao, Eman M. M. Abdelraheem, Constantinos G. Neochoritis, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, David C. McGowan, Alexander Dömling

Onderzoeksoutput › Academic › peer review

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The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

Originele taal-2	English
Pagina's (van-tot)	4980-4983
Aantal pagina's	4
Tijdschrift	Organic letters
Volume	17
Nummer van het tijdschrift	20
DOI's	https://doi.org/10.1021/acs.orglett.5b02419
Status	Published - 16-okt.-2015

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Versatile Multicomponent Reaction Macrocycle Synthesis Using α-IsocyanoFinal publisher's version, 1,63 MBLicentie: Taverne

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CCDC 1408649: Experimental Crystal Structure Determination
Liao, G. (Contributor), Abdelraheem, E. (Contributor), Neochoritis, D. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłus̈cik, J. (Contributor), McGowan, D. C. (Contributor) & Dömling, A. (Contributor), University of Groningen, 24-jun.-2015
DOI: 10.5517/cc1j8t9x
Dataset
CCDC 1408650: Experimental Crystal Structure Determination
Liao, G. (Contributor), Abdelraheem, E. (Contributor), Neochoritis, D. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłus̈cik, J. (Contributor), McGowan, D. C. (Contributor) & Dömling, A. (Contributor), University of Groningen, 24-jun.-2015
DOI: 10.5517/cc1j8tby
Dataset
CCDC 1408654: Experimental Crystal Structure Determination
Liao, G. (Contributor), Abdelraheem, E. (Contributor), Neochoritis, D. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłus̈cik, J. (Contributor), McGowan, D. C. (Contributor) & Dömling, A. (Contributor), University of Groningen, 24-jun.-2015
DOI: 10.5517/cc1j8tg2
Dataset

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@article{a857b0c6de70400a8ed26609ca7dc994,

title = "Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids",

abstract = "The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.",

author = "Liao, {George P.} and Abdelraheem, {Eman M. M.} and Neochoritis, {Constantinos G.} and Katarzyna Kurpiewska and Justyna Kalinowska-T{\l}u{\'s}cik and McGowan, {David C.} and Alexander D{\"o}mling",

year = "2015",

month = oct,

day = "16",

doi = "10.1021/acs.orglett.5b02419",

language = "English",

volume = "17",

pages = "4980--4983",

journal = "Organic letters",

issn = "1523-7060",

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TY - JOUR

T1 - Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

AU - Liao, George P.

AU - Abdelraheem, Eman M. M.

AU - Neochoritis, Constantinos G.

AU - Kurpiewska, Katarzyna

AU - Kalinowska-Tłuścik, Justyna

AU - McGowan, David C.

AU - Dömling, Alexander

PY - 2015/10/16

Y1 - 2015/10/16

N2 - The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

AB - The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

U2 - 10.1021/acs.orglett.5b02419

DO - 10.1021/acs.orglett.5b02419

M3 - Article

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SN - 1523-7060

VL - 17

SP - 4980

EP - 4983

JO - Organic letters

JF - Organic letters

IS - 20

ER -

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

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Datasets

CCDC 1408649: Experimental Crystal Structure Determination

CCDC 1408650: Experimental Crystal Structure Determination

CCDC 1408654: Experimental Crystal Structure Determination

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