Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy

Kyrre E. Emblem*, Kim Mouridsen, Atle Bjornerud, Christian T. Farrar, Dominique Jennings, Ronald J. H. Borra, Patrick Y. Wen, Percy Ivy, Tracy T. Batchelor, Bruce R. Rosen, Rakesh K. Jain, A. Gregory Sorensen

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    160 Citaten (Scopus)

    Samenvatting

    Measurement of vessel caliber by magnetic resonance imaging (MRI) is a valuable technique for in vivo monitoring of hemodynamic status and vascular development, especially in the brain. Here, we introduce a new paradigm in MRI termed vessel architectural imaging (VAI) that exploits an overlooked temporal shift in the magnetic resonance signal, forming the basis for vessel caliber estimation, and show how this phenomenon can reveal new information on vessel type and function not assessed by any other noninvasive imaging technique. We also show how this biomarker can provide new biological insights into the treatment of patients with cancer. As an example, we demonstrate using VAI that anti-angiogenic therapy can improve microcirculation and oxygen saturation and reduce vessel calibers in patients with recurrent glioblastomas and, more crucially, that patients with these responses have prolonged survival. Thus, VAI has the potential to identify patients who would benefit from therapies.

    Originele taal-2English
    Pagina's (van-tot)1178-1183
    Aantal pagina's6
    TijdschriftNature Medicine
    Volume19
    Nummer van het tijdschrift9
    DOI's
    StatusPublished - sep-2013

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