This thesis therefore tested if vitamin D status is of importance in prevention and treatment of disease, and in particular heart failure. It describes that individuals with low levels of vitamin D often have more diseases, including cardiovascular disease. However, it also shows that in an experimental heart failure model, vitamin D supplementation does not reduce thickness of heart muscle wall, although it protects against stiffness and amount of scar tissue in the heart muscle. It appears that vitamin D and parathyroid hormone are no predictors of heart failure. The role for vitamin D as novel target in heart failure is not straightforward and may be limited. Nevertheless, at this stage, a potential utility of vitamin D supplementation or VDR activation cannot be ruled out yet.
This thesis furthermore shows that low levels of vitamin D during pregnancy may influence health status in the offspring. Vitamin D deficiency has been related to epigenetic changes that are associated with increase in blood pressure. Low vitamin D in adults could therefore not only be a risk factor for development of disease in an individual, but could also affect future generation(s).
|Kwalificatie||Master of Philosophy|
|Datum van toekenning||23-nov-2015|
|Plaats van publicatie||[Groningen]|
|Status||Published - 2015|
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, H. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006