Vivosorb (R), Bio-Gide (R), and Gore-Tex (R) as barrier membranes in rat mandibular defects: an evaluation by microradiography and micro-CT

Pepijn F. M. Gielkens*, Jurjen Schortinghuis, Johan R. de Jong, Gerry M. Raghoebar, Boudewijn Stegenga, Ruud R. M. Bos

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

39 Citaten (Scopus)


Objectives: The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb (R)) composed of poly(DL-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes.

Material and methods: In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (mu CT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model.

Results: New bone formation could be detected by post-mortem microradiography in 130 samples and by mu CT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes.

Conclusions: In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.

Originele taal-2English
Pagina's (van-tot)516-521
Aantal pagina's6
Nummer van het tijdschrift5
StatusPublished - mei-2008

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