von Willebrand disease and aging: An evolving phenotype

Y. V. Sanders, M. A. Giezenaar, B. A. P. Laros-van Gorkom, K. Meijer, J. G. van der Bom, M. H. Cnossen, M. R. Nijziel, P. F. Ypma, K. Fijnvandraat, J. Eikenboom, E. P. Mauser-Bunschoten, F. W. G. Leebeek*, WiN Study Grp

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    65 Citaten (Scopus)

    Samenvatting

    Background: Because the number of elderly von Willebrand disease (VWD) patients is increasing, the pathophysiology of aging in VWD has become increasingly relevant. Objectives: To assess age-related changes in von Willebrand factor (VWF) and factor VIII (FVIII) levels and to compare age-related differences in bleeding phenotype between elderly VWD patients and those <65 years. We also studied co-morbidity in elderly patients. Patients/Methods: We included VWD patients with VWF levels

    Originele taal-2English
    Pagina's (van-tot)1066-1075
    Aantal pagina's10
    TijdschriftJournal of Thrombosis and Haemostasis
    Volume12
    Nummer van het tijdschrift7
    DOI's
    StatusPublished - jul-2014

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