Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [11C] raclopride data

Miho Shidahara*, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico E. Turkheimer

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review


The purpose of this study was the evaluation of a wavelet-based resolution recovery (RR) method, named structural and functional synergy for RR (SFS-RR), for a variety of simulated human brain [11C]raclopride PET images. Simulated datasets of 15 human phantoms were processed by SFS-RR using an anatomical prior. This anatomical information was in the form of a hybrid segmented-atlas, which combines an MRI for anatomical labelling and a PET image for functional labelling of each anatomical structure. First, the relationship between the FWHM of the original the PET image and its resolution recovered version was investigated. Then quantitative evaluation was performed by comparing caudate, putamen and cerebellum regions of the true image; simulated PET image; and RR image. The spatial resolution of the original PET image effected on how accurately SFS-RR recovers the image counts in striatum regions. The resolution in striatum, and cerebellum regions was successfully recovered for all the 15 human phantoms. The proposed methodology proved effective in the resolution recovery of small structures of brain [11C]raclopride PET images. The improvement was consistent across the anatomical variability of a simulated population, provided accurate anatomical segmentations are available.

Originele taal-2English
Titel2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
UitgeverijInstitute of Electrical and Electronics Engineers Inc.
Aantal pagina's5
ISBN van geprinte versie9781467301183
StatusPublished - 2011
Extern gepubliceerdJa
Evenement2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 - Valencia, Spain
Duur: 23-okt.-201129-okt.-2011

Publicatie series

NaamIEEE Nuclear Science Symposium Conference Record
ISSN van geprinte versie1095-7863


Conference2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011

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