WNT Signalling in Lung Physiology and Pathology

Yan Hu, Chiara Ciminieri, Qianjiang Hu, Mareike Lehmann, Melanie Königshoff, Reinoud Gosens*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ChapterAcademicpeer review

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The main physiological function of the lung is gas exchange, mediated at the interface between the alveoli and the pulmonary microcapillary network and facilitated by conducting airway structures that regulate the transport of these gases from and to the alveoli. Exposure to microbial and environmental factors such as allergens, viruses, air pollution, and smoke contributes to the development of chronic lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. Respiratory diseases as a cluster are the commonest cause of chronic disease and of hospitalization in children and are among the three most common causes of morbidity and mortality in the adult population worldwide. Many of these chronic respiratory diseases are associated with inflammation and structural remodelling of the airways and/or alveolar tissues. They can often only be treated symptomatically with no disease-modifying therapies that normalize the pathological tissue destruction driven by inflammation and remodelling. In search for novel therapeutic strategies for these diseases, several lines of evidence revealed the WNT pathway as an emerging target for regenerative strategies in the lung. WNT proteins, their receptors, and signalling effectors have central regulatory roles under (patho)physiological conditions underpinning lung function and (chronic) lung diseases and we summarize these roles and discuss how pharmacological targeting of the WNT pathway may be utilized for the treatment of chronic lung diseases.

Originele taal-2English
TitelPharmacology of the WNT Signaling System
RedacteurenGunnar Schulte, Pawel Kozielewicz
UitgeverijSpringer Science and Business Media Deutschland GmbH
Pagina's305-336
Aantal pagina's32
DOI's
StatusPublished - 2021

Publicatie series

NaamHandbook of Experimental Pharmacology
Volume269
ISSN van geprinte versie0171-2004
ISSN van elektronische versie1865-0325

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